HMGCS1 Polyclonal Antibody | G-AB-10406
Gentaur Antibodies
Write a Review
Gentaur Antibodies
HMGCS1 Polyclonal Antibody | G-AB-10406
- SKU:
- G-AB-10406
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
HMGCS1 Polyclonal Antibody | G-AB-10406 | Gentaur Antibodies
Overview: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction
Synonyms: HMGCS1, HMGCS
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 3157
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human HMGCS1 (NP_002121.4) .
Clone #:
Conjugation: Unconjugated
Swissprot: Q01581
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IF
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Related Products
