HUS1 Polyclonal Antibody | G-AB-10636

HUS1 Polyclonal Antibody | G-AB-10636 | Gentaur Antibodies

Overview: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC) , which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: HUS1, hHUS1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 3364

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HUS1 (NP_004498.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O60921

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HUS1 Polyclonal Antibody DataSheet