IFITM1 Polyclonal Antibody | G-AB-10450

IFITM1 Polyclonal Antibody | G-AB-10450 | Gentaur Antibodies

Overview: Interferons (IFNs) are potential antitumor agents, as they exhibit antiproliferative and differentiating properties, in addition to functioning in the defense against microbial infections. IFN exposure induces the regulation of expression levels of cellular proteins that mediate the pleiotropic effects of interferons. These effects may be mediated by soluble factors or by cell-cell interactions involving specific membrane proteins. The IFITM family of proteins are transmembrane proteins so named because their expression is IFN-inducible. IFITM proteins have been found upregulated in human colorectal carcinomas. Both mouse IFITM1 (also known as CD225) and IFITM3 demonstrate expression on the cell surfaces of primordial germ cells in a developmentally-regulated manner. They presumably modulate cell adhesion and influence cell differentiation. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Signal Transduction, Stem Cells

Synonyms: IFITM1, 9-27, CD225, DSPA2a, IFI17, LEU13

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 8519

Accession #:

Clonality:

Immunogen: A synthetic peptide of human IFITM1 (NP_003632.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: P13164

Santa Cruz:

Calculated MW: 13 kDa

Observed MW: 17 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:200-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IFITM1 Polyclonal Antibody DataSheet