IGHA1 Polyclonal Antibody | G-AB-04176

IGHA1 Polyclonal Antibody | G-AB-04176 | Gentaur Antibodies

Overview: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) . Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: FLJ14473, FLJ35065, FLJ35500, FLJ36402, FLJ39698, FLJ40001, FLJ41548, FLJ41552, FLJ41789, FLJ43248, FLJ43594, FLJ44293, FLJ46028, FLJ46621, FLJ46724, FLJ46811, FLJ46824, FLJ90170, Ig alpha 1 chain C region, IgA1, IGHA1, immunoglobulin heavy constant alpha 1, MGC102857

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC005951

Clonality: Polyclonal

Immunogen: Fusion protein of human IGHA1

Clone #:

Conjugation: Unconjugated

Swissprot: P01876

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.14 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IGHA1 Polyclonal Antibody DataSheet