IRGC Polyclonal Antibody | G-AB-03830

IRGC Polyclonal Antibody | G-AB-03830 | Gentaur Antibodies

Overview: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology, Signal Transduction

Synonyms: F630044M05Rik, Gm1102, Gm474, IIGP5, IIGP5, Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, IRGC, IRGC1, RGD1311107

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP062558

Clonality: Polyclonal

Immunogen: Synthetic peptide of human IRGC

Clone #:

Conjugation: Unconjugated

Swissprot: Q6NXR0

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.78 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IRGC Polyclonal Antibody DataSheet