KIR3DL3 Polyclonal Antibody | G-AB-07300

KIR3DL3 Polyclonal Antibody | G-AB-07300 | Gentaur Antibodies

Overview: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) , while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: KIR3DL3, CD158Z, KIR3DL7, KIR44, KIRC1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 115653

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human KIR3DL3 (NP_703144.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q8N743

Santa Cruz:

Calculated MW: 44 kDa

Observed MW: 45 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

KIR3DL3 Polyclonal Antibody DataSheet