LCP2 Polyclonal Antibody | G-AB-08289

LCP2 Polyclonal Antibody | G-AB-08289 | Gentaur Antibodies

Overview: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: LCP2, SLP-76, SLP76

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 3937

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human LCP2 (NP_005556.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13094

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

LCP2 Polyclonal Antibody DataSheet