LSM10 Polyclonal Antibody | G-AB-06422

LSM10 Polyclonal Antibody | G-AB-06422 | Gentaur Antibodies

Overview: LSm10 (U7 snRNA-associated Sm-like protein LSm10) is a nuclear protein that belongs to the snRNP (small nuclear ribonucleoproteins) Sm protein family. The survival of motor neurons (SMN) complex mediates the assembly of snRNPs involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. LSm10 and LSm11, mammalian homologs of the yeast Sm proteins D1 and D2, are important for U7 snRNP function and subcellular localization. U7 snRNP is an RNA molecule involved in the splicing of animal histone pre-mRNAs. Lsm10 and Lsm11 also associate with pICln (Chloride ion current inducer protein) , which interacts with Sm proteins to inhibit their assembly on U RNA. LSm10 interactions with U7 snRNA and pICln may provide the means for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, potentially leading to advances in antisense gene therapy.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling

Synonyms: LSM 10, LSM10 U7 small nuclear RNA associated, MGC15749, MST074, MSTP074, U7 snRNA associated Sm like protein LSm10, U7 snRNP specific Sm like protein LSM10

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC007623

Clonality: Polyclonal

Immunogen: Fusion protein of human LSM10

Clone #:

Conjugation: Unconjugated

Swissprot: Q969L4

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.8 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

LSM10 Polyclonal Antibody DataSheet