MKP-1 Polyclonal Antibody | G-AB-01271
Gentaur Antibodies
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Gentaur Antibodies
MKP-1 Polyclonal Antibody | G-AB-01271
- SKU:
- G-AB-01271
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
MKP-1 Polyclonal Antibody | G-AB-01271 | Gentaur Antibodies
Overview: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Signal Transduction
Synonyms: CL 100, CL100, Dual Specificity Phosphatase 1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, DUS1, DUSP 1, Dusp1, HVH1, MAP kinase phosphatase 1, Mitogen-activated protein kinase phosphatase 1, MKP-1, MKP1, Protein tyrosine phosphatase CL100, Protein-tyrosine phosphatase CL100, PTPN10, Serine/threonine specific protein phosphatase, VH1
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP_004408
Clonality: Polyclonal
Immunogen: Synthetic peptide of human DUSP1
Clone #:
Conjugation: Unconjugated
Swissprot: P28562
Santa Cruz: sc-10796/sc-370/sc-1199/sc-1102
Calculated MW: 39 kDa
Observed MW:
Concentration: 0.4 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:200-1:1000, IHC 1:25-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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