MLKL Polyclonal Antibody | G-AB-08244
Gentaur Antibodies
- SKU:
- G-AB-08244
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
MLKL Polyclonal Antibody | G-AB-08244 | Gentaur Antibodies
Overview: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3) , which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Category Type: Polyclonal Antibody
Research Areas:
Synonyms: MLKL, hMLKL
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID: 74568
Accession #:
Clonality:
Immunogen: Recombinant protein of mouse MLKL
Clone #:
Conjugation: Unconjugated
Swissprot: Q9D2Y4
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.