MLKL Polyclonal Antibody | G-AB-10724

MLKL Polyclonal Antibody | G-AB-10724 | Gentaur Antibodies

Overview: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3) , which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: MLKL, hMLKL

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 74568

Accession #:

Clonality:

Immunogen: Recombinant protein of mouse MLKL

Clone #:

Conjugation: Unconjugated

Swissprot: Q9D2Y4

Santa Cruz:

Calculated MW: 53 kDa/54 kDa

Observed MW: 54 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MLKL Polyclonal Antibody DataSheet