MMP2 Polyclonal Antibody | G-AB-10995

MMP2 Polyclonal Antibody | G-AB-10995 | Gentaur Antibodies

Overview: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in Signal Transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Cardiovascular, Metabolism

Synonyms: CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, MMP2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4313

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human MMP2 (NP_004521.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P08253

Santa Cruz:

Calculated MW: 65 kDa/68 kDa/73 kDa

Observed MW: 73 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MMP2 Polyclonal Antibody DataSheet