MUS81 Polyclonal Antibody | G-AB-11336

MUS81 Polyclonal Antibody | G-AB-11336 | Gentaur Antibodies

Overview: This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: MUS81, SLX3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 80198

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human MUS81 (NP_079404.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q96NY9

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MUS81 Polyclonal Antibody DataSheet