NUAK1 Polyclonal Antibody | G-AB-01552

NUAK1 Polyclonal Antibody | G-AB-01552 | Gentaur Antibodies

Overview: NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5 (ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: AMP activated protein kinase family member 5, AMPK related protein kinase 5, AMPK-related protein kinase 5, NUAK family SNF1 like kinase, NUAK family SNF1-like kinase 1, Nuak1, NUAK1, Omphalocele kinase 1, Probable serine/threonine protein kinase KIAA0537

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_055655

Clonality: Polyclonal

Immunogen: Synthetic peptide of human NUAK1

Clone #:

Conjugation: Unconjugated

Swissprot: O60285

Santa Cruz: sc-49366/sc-130117

Calculated MW:

Observed MW:

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NUAK1 Polyclonal Antibody DataSheet