NUAK1 Polyclonal Antibody | G-AB-09697
Gentaur Antibodies
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Gentaur Antibodies
NUAK1 Polyclonal Antibody | G-AB-09697
- SKU:
- G-AB-09697
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Rat
NUAK1 Polyclonal Antibody | G-AB-09697 | Gentaur Antibodies
Overview: NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5 (ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Signal Transduction
Synonyms: NUAK1, ARK5
Reactivity: Human, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 9891
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human NUAK1 (NP_055655.1) .
Clone #:
Conjugation: Unconjugated
Swissprot: O60285
Santa Cruz:
Calculated MW: 23 kDa/74 kDa
Observed MW: 74 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB
Dilution: WB 1:200-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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