p16 Polyclonal Antibody | G-AB-00224

p16 Polyclonal Antibody | G-AB-00224 | Gentaur Antibodies

Overview: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: CCM2, CDK4 inhibitor p16 INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) , Cyclin Dependent Kinase Inhibitor 2A

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein

Clone #:

Conjugation: Unconjugated

Swissprot: Q9R0Z3

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.82 mg/mL

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification method: Antigen Affinity Purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

p16 Polyclonal Antibody DataSheet