p27 KIP 1 Polyclonal Antibody | G-AB-09122

p27 KIP 1 Polyclonal Antibody | G-AB-09122 | Gentaur Antibodies

Overview: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, p27 KIP 1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1027

Accession #:

Clonality:

Immunogen: A synthetic peptide of human p27 KIP 1 (NP_004055.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P46527

Santa Cruz:

Calculated MW: 22 kDa

Observed MW: 30 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

p27 KIP 1 Polyclonal Antibody DataSheet