PDGFB Polyclonal Antibody | G-AB-05273

PDGFB Polyclonal Antibody | G-AB-05273 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB) , where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Developmental Biology, Signal Transduction

Synonyms: Becaplermin, PDGF 2, PDGF B chain, PDGF subunit B, PDGF-2, PDGF2, Pdgfb, PDGFB, Platelet derived growth factor 2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Platelet-derived growth factor subunit B, Proto-oncogene c-Sis, SIS, SSV

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PDGFB

Clone #:

Conjugation: Unconjugated

Swissprot:

Santa Cruz:

Calculated MW: 27 kDa

Observed MW: 27 kDa

Concentration: 410 μg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000, IHC 1:200-1:400

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PDGFB Polyclonal Antibody DataSheet