PFKFB3 Polyclonal Antibody | G-AB-05180

PFKFB3 Polyclonal Antibody | G-AB-05180 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP) , and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cardiovascular, Signal Transduction, Neuroscience, Cancer, Metabolism

Synonyms: Renal Carcinoma Antigen NY-REN-56, PFK/FBPase 3, IPFK2, PFK2

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP004557

Clonality: Polyclonal

Immunogen: Synthetic peptide of human PFKFB3

Clone #:

Conjugation: Unconjugated

Swissprot: Q16875

Santa Cruz:

Calculated MW: 60 kDa

Observed MW: Refer to figures

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PFKFB3 Polyclonal Antibody DataSheet