PFKFB3 Polyclonal Antibody | G-AB-11391

PFKFB3 Polyclonal Antibody | G-AB-11391 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP) , and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cardiovascular, Signal Transduction, Neuroscience, Cancer, Metabolism

Synonyms: PFKFB3, IPFK2, PFK2, iPFK-2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5209

Accession #:

Clonality:

Immunogen: A synthetic peptide of human PFKFB3 (NP_004557.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q16875

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PFKFB3 Polyclonal Antibody DataSheet