PHKB Polyclonal Antibody | G-AB-12001

PHKB Polyclonal Antibody | G-AB-12001 | Gentaur Antibodies

Overview: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: PHKB

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 5257

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PHKB (NP_000284.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q93100

Santa Cruz:

Calculated MW: 123 kDa/124 kDa

Observed MW: 125 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PHKB Polyclonal Antibody DataSheet