PIWIL4 Polyclonal Antibody | G-AB-08101

PIWIL4 Polyclonal Antibody | G-AB-08101 | Gentaur Antibodies

Overview: PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: PIWIL4, HIWI2, MIWI2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 143689

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PIWIL4 (NP_689644.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q7Z3Z4

Santa Cruz:

Calculated MW: 52 kDa/56 kDa/96 kDa

Observed MW: 105 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PIWIL4 Polyclonal Antibody DataSheet