PPARA Polyclonal Antibody | G-AB-00044

PPARA Polyclonal Antibody | G-AB-00044 | Gentaur Antibodies

Overview: Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1) , acyl-CoA oxidase, and NADPH oxidase.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction

Synonyms: hPPAR, MGC2237, MGC2452, NR1C1, Nuclear receptor subfamily 1 group C member 1, OTTHUMP00000197740, OTTHUMP00000197741, Peroxisome proliferative activated receptor alpha, Peroxisome proliferator activated receptor alpha, Peroxisome proliferator-activated receptor alpha, PPAR, PPAR-alpha, ppara, PPARA, PPARalpha

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_005027

Clonality: Polyclonal

Immunogen: Recombinant human Peroxisome proliferator-activated receptor alpha protein

Clone #:

Conjugation: Unconjugated

Swissprot: Q07869

Santa Cruz: sc-1985, sc-1982, sc-9000

Calculated MW: 52 kDa

Observed MW: 52 kDa

Concentration: 2 mg/mL

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PPARA Polyclonal Antibody DataSheet