PSMD2 Polyclonal Antibody | G-AB-09878

PSMD2 Polyclonal Antibody | G-AB-09878 | Gentaur Antibodies

Overview: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology

Synonyms: PSMD2, P97, RPN1, S2, TRAP2

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 5708

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PSMD2 (NP_002799.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13200

Santa Cruz:

Calculated MW: 82 kDa/85 kDa/100 kDa

Observed MW: 108 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PSMD2 Polyclonal Antibody DataSheet