PTTG1 Polyclonal Antibody | G-AB-12130

PTTG1 Polyclonal Antibody | G-AB-12130 | Gentaur Antibodies

Overview: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: PTTG1, EAP1, HPTTG, PTTG, TUTR1, securin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 9232

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PTTG1 (NP_001269311.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O95997

Santa Cruz:

Calculated MW: 22 kDa

Observed MW: 24 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PTTG1 Polyclonal Antibody DataSheet