RAF1 Polyclonal Antibody | G-AB-07137

RAF1 Polyclonal Antibody | G-AB-07137 | Gentaur Antibodies

Overview: This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K) , which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms: CMD1NN, CRAF, NS5, Raf-1, c-Raf, RAF1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5894

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human RAF1 (NP_002871.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P04049

Santa Cruz:

Calculated MW: 73 kDa/75 kDa

Observed MW: 73 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RAF1 Polyclonal Antibody DataSheet