RAG2 Polyclonal Antibody | G-AB-07818

RAG2 Polyclonal Antibody | G-AB-07818 | Gentaur Antibodies

Overview: This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: RAG2, RAG-2

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 5897

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human RAG2 (NP_001230715.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P55895

Santa Cruz:

Calculated MW: 59 kDa

Observed MW: 59 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RAG2 Polyclonal Antibody DataSheet