RHOA Polyclonal Antibody | G-AB-05496

RHOA Polyclonal Antibody | G-AB-05496 | Gentaur Antibodies

Overview: Regulates a Signal Transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: Aplysia ras related homolog 12, ARH12, ARHA, H 12, H12, Oncogene RHO H12, Ras homolog family member A, Ras homolog gene family member A, Rho A, Rho cDNA clone 12, RHO H12, RHO12, RHOA, RHOA, RHOH12, Small GTP binding protein Rho A, Transforming protein Rho A, Transforming protein RhoA

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse RhoA .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9QUI0, P61589

Santa Cruz:

Calculated MW: 22 kDa

Observed MW: 22 kDa

Concentration: 0.9 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RHOA Polyclonal Antibody DataSheet