RNASEH2A Polyclonal Antibody | G-AB-08954

RNASEH2A Polyclonal Antibody | G-AB-08954 | Gentaur Antibodies

Overview: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2) . RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS) , a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: RNASEH2A, AGS4, JUNB, RNASEHI, RNHIA, RNHL

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10535

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human RNASEH2A (NP_006388.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: O75792

Santa Cruz:

Calculated MW: 33 kDa

Observed MW: 33 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RNASEH2A Polyclonal Antibody DataSheet