SFPQ Polyclonal Antibody | G-AB-07259

SFPQ Polyclonal Antibody | G-AB-07259 | Gentaur Antibodies

Overview: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: SFPQ, POMP100, PPP1R140, PSF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 6421

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human SFPQ (NP_005057.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P23246

Santa Cruz:

Calculated MW: 72 kDa/76 kDa

Observed MW: 115 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SFPQ Polyclonal Antibody DataSheet