SMAD4 Polyclonal Antibody | G-AB-10762

SMAD4 Polyclonal Antibody | G-AB-10762 | Gentaur Antibodies

Overview: This gene encodes a member of the Smad family of Signal Transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE) . The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem cells

Synonyms: DPC4, JIP, MADH4, MYHRS, Smad4, SMAD4

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4089

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human SMAD4 (NP_005350.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13485

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SMAD4 Polyclonal Antibody DataSheet