SMG7 Polyclonal Antibody | G-AB-09039

SMG7 Polyclonal Antibody | G-AB-09039 | Gentaur Antibodies

Overview: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling

Synonyms: SMG7, C1orf16, EST1C, SGA56M

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 9887

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human SMG7 (NP_963863.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q92540

Santa Cruz:

Calculated MW: 122 kDa/127 kDa/131 kDa

Observed MW: 127 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:200-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SMG7 Polyclonal Antibody DataSheet