SRGAP3 Polyclonal Antibody | G-AB-01184

SRGAP3 Polyclonal Antibody | G-AB-01184 | Gentaur Antibodies

Overview: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience, Signal Transduction

Synonyms: ARHGAP 14, ARHGAP14, Gbi, ME GAP, MEGAP, Mental disorder associated GAP, Mental disorder-associated GAP, Rho GTPase activating protein 14, Rho GTPase-activating protein 14, SLIT ROBO Rho GTPase activating protein 3, SLIT-ROBO Rho GTPase-activating protein 3, srGAP 2, srGAP 3, srGAP2, srGAP3, SRGP 2, SRGP2, SRGP3, WAVE associated Rac GTPase activating protein, WAVE-associated Rac GTPase-activating protein, WRP

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC039300

Clonality: Polyclonal

Immunogen: Recombinant protein of human SRGAP3

Clone #:

Conjugation: Unconjugated

Swissprot: O43295

Santa Cruz: sc-134955

Calculated MW:

Observed MW:

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SRGAP3 Polyclonal Antibody DataSheet