SRPK2 Polyclonal Antibody | G-AB-04499

SRPK2 Polyclonal Antibody | G-AB-04499 | Gentaur Antibodies

Overview: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: Human serine kinase SRPK2 mRNA, complete cds, Serine kinase SRPK2, Serine/arginine rich protein specific kinase 2, Serine/arginine-rich protein-specific kinase 2, Serine/threonine protein kinase SRPK2, SFRS protein kinase 2, SFRSK2, SR protein specific kinase 2, SR-protein-specific kinase 2, SRPK2, SRPK2, SRSF protein kinase 2 C-terminal

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC035214

Clonality: Polyclonal

Immunogen: Fusion protein of human SRPK2

Clone #:

Conjugation: Unconjugated

Swissprot: P78362

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.56 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:100-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SRPK2 Polyclonal Antibody DataSheet