TGFB2 Polyclonal Antibody | G-AB-10361

TGFB2 Polyclonal Antibody | G-AB-10361 | Gentaur Antibodies

Overview: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t (1;7) (q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction, Stem Cells

Synonyms: TGFB2, G-TSF, LDS4, TGF-beta2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7042

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TGFB2 (NP_001129071.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P61812

Santa Cruz:

Calculated MW: 47 kDa/50 kDa

Observed MW: 55 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:200-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TGFB2 Polyclonal Antibody DataSheet