TGFBR2 Polyclonal Antibody | G-AB-00369
Gentaur Antibodies
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Gentaur Antibodies
TGFBR2 Polyclonal Antibody | G-AB-00369
- SKU:
- G-AB-00369
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
TGFBR2 Polyclonal Antibody | G-AB-00369 | Gentaur Antibodies
Overview: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction, Stem Cells
Synonyms: AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TbetaR II, TGF beta receptor type 2, TGFB R2, Tgfbr2, Transforming growth factor beta receptor II
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID: 7048
Accession #:
Clonality: Polyclonal
Immunogen: Recombinant Human TGF-beta receptor type-2 protein
Clone #:
Conjugation: Unconjugated
Swissprot: P37173
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 0.75 mg/mL
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3
Purification method: Antigen Affinity Purification
Application: IHC
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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