TOP2A Polyclonal Antibody | G-AB-09436

TOP2A Polyclonal Antibody | G-AB-09436 | Gentaur Antibodies

Overview: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: TOP2A, TOP2, TP2A

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 7153

Accession #:

Clonality:

Immunogen: A synthetic peptide of human TOP2A (NP_001058.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P11388

Santa Cruz:

Calculated MW: 174 kDa/177 kDa/178 kDa/182 kDa

Observed MW: 182 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TOP2A Polyclonal Antibody DataSheet