TRAF6 Polyclonal Antibody | G-AB-03927

TRAF6 Polyclonal Antibody | G-AB-03927 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate Signal Transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Immunology, Signal Transduction

Synonyms: E3 ubiquitin-protein ligase TRAF6, Interleukin 1 signal transducer, Interleukin-1 signal transducer, MGC 3310, MGC:3310, MGC3310, OTTHUMP00000232772, OTTHUMP00000232773, RING finger protein 85, RNF 85, RNF85, TNF receptor associated factor 6, TNF receptor-associated factor 6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase, TRAF 6, Traf6, TRAF6

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC031052

Clonality: Polyclonal

Immunogen: Fusion protein of human TRAF6

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Y4K3

Santa Cruz:

Calculated MW: 60 kDa

Observed MW: Refer to figures

Concentration: 0.54 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TRAF6 Polyclonal Antibody DataSheet