TTN Polyclonal Antibody | G-AB-09527
Gentaur Antibodies
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Gentaur Antibodies
TTN Polyclonal Antibody | G-AB-09527
- SKU:
- G-AB-09527
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Mouse, Rat
TTN Polyclonal Antibody | G-AB-09527 | Gentaur Antibodies
Overview: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.
Category Type: Polyclonal Antibody
Research Areas: Cardiovascular, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms: TTN, CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD, SALMY, titin
Reactivity: Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 7273
Accession #:
Clonality:
Immunogen: Recombinant Protein of human TTN.
Clone #:
Conjugation: Unconjugated
Swissprot: Q8WZ42
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IF
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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