TXNRD2 Polyclonal Antibody | G-AB-10687

TXNRD2 Polyclonal Antibody | G-AB-10687 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism

Synonyms: TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 10587

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TXNRD2 (NP_006431.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9NNW7

Santa Cruz:

Calculated MW: 30 kDa/46 kDa/53 kDa/56 kDa

Observed MW: 56 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TXNRD2 Polyclonal Antibody DataSheet