TYROBP Polyclonal Antibody | G-AB-10626

TYROBP Polyclonal Antibody | G-AB-10626 | Gentaur Antibodies

Overview: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating Signal Transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in Signal Transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) , also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2) , also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: TYROBP, DAP12, KARAP, PLOSL

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7305

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TYROBP (NP_003323.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O43914

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TYROBP Polyclonal Antibody DataSheet