UPF3A Polyclonal Antibody | G-AB-09240

UPF3A Polyclonal Antibody | G-AB-09240 | Gentaur Antibodies

Overview: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: UPF3A, HUPF3A, RENT3A, UPF3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 65110

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human UPF3A (NP_075387.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9H1J1

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

UPF3A Polyclonal Antibody DataSheet