XBP1 Polyclonal Antibody | G-AB-08839

XBP1 Polyclonal Antibody | G-AB-08839 | Gentaur Antibodies

Overview: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER) , the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1) . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S) , which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1 (U) , is constitutively expressed, and thought to function as a negative feedback regulator of XBP1 (S) , which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: XBP1, TREB-5, TREB5, XBP-1, XBP2, XBP1s, CBX1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 7494

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human XBP1 (NP_005071.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P17861

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

XBP1 Polyclonal Antibody DataSheet