ZBTB33 Polyclonal Antibody | G-AB-07948

ZBTB33 Polyclonal Antibody | G-AB-07948 | Gentaur Antibodies

Overview: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2) . Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1) , which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: ZBTB33, ZNF-kaiso, ZNF348

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 10009

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ZBTB33 (NP_006768.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q86T24

Santa Cruz:

Calculated MW: 74 kDa

Observed MW: 74 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:1000-1:3000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ZBTB33 Polyclonal Antibody DataSheet