EPA Method 3542A

This method describes the extraction of semivolatile organic compounds from samples collected by Method 0010. This method replaces the Sample Preparation section of Method 0010 (Modified Method 5 Sampling Train, also known as SemiVOST), which currently addresses preparation of Method 0010 train components for analysis with very little detail.

Although this sample preparation technique is intended primarily for gas chromatography/mass spectrometric (GC/MS) analysis following Method 8270, the extracts prepared according to this method may be used with other analytical methods. The Method 0010 sampling train collects semivolatile organic compounds with boiling points above 100EC. Some of these semivolatile organic compounds may not be amenable to gas chromatography and will require the application of high performance liquid chromatography (HPLC) for quantitative analysis. The use of HPLC coupled with mass spectrometry (HPLC/MS) is an analytical technique that may also be applied.

A solvent exchange from methylene chloride to a more polar solvent such as acetonitrile or extraction with a solvent other than methylene chloridewill probably be required for successful application of HPLC techniques. Some semivolatile analytes may require derivatization for successful GC/MS analysis. 1.3 Prior to employing this method, analysts are advised to consult the base method for each type of procedure that may be employed in the overall analysis (e.g., Methods 3500, 3600, 5000, and 8000). Analysts also should consult the disclaimer statement at the front of the manual and the information in Chapter Two for guidance on the intended flexibility in the choice of methods, apparatus, materials, reagents, and supplies, and on the responsibilities of the analyst for demonstrating that the techniques employed are appropriate for the analytes of interest, in the matrix of interest, and at the levels of concern.

In addition, analysts and data users are advised that, except where explicitly specified in a regulation, the use of SW-846 methods is not mandatory in response to Federal testing requirements. The information contained in this method is provided by EPA as guidance to be used by the analyst and the regulated community in making judgments necessary to generate results that meet the data quality objectives for the intended application.