BRCA1 Polyclonal Antibody | G-AB-00467
Gentaur Antibodies
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Gentaur Antibodies
BRCA1 Polyclonal Antibody | G-AB-00467
- SKU:
- G-AB-00467
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
BRCA1 Polyclonal Antibody | G-AB-00467 | Gentaur Antibodies
Overview: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: BRCA 1, BRCA1, BRCA1 DNA repair associated, BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, BRCA1, BRCAI, BRCC 1, BRCC1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: BC072418
Clonality: Polyclonal
Immunogen: Recombinant protein of human BRCA1
Clone #:
Conjugation: Unconjugated
Swissprot: P38398
Santa Cruz: sc-641/sc-642/sc-1021/sc-7867/sc-28234/sc-646
Calculated MW:
Observed MW:
Concentration: 0.3 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: IHC, ELISA
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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