CRH Polyclonal Antibody | G-AB-07508

CRH Polyclonal Antibody | G-AB-07508 | Gentaur Antibodies

Overview: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Signal Transduction

Synonyms: CRH, CRF, CRH1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1392

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CRH (NP_000747.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P06850

Santa Cruz:

Calculated MW: 21 kDa

Observed MW: 35 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CRH Polyclonal Antibody DataSheet