DMP1 Polyclonal Antibody | G-AB-09556

DMP1 Polyclonal Antibody | G-AB-09556 | Gentaur Antibodies

Overview: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction, Stem Cells, Developmental Biology

Synonyms: DMP1, ARHP, ARHR, DMP-1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1758

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human DMP1 (NP_004398.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13316

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DMP1 Polyclonal Antibody DataSheet