DMP1 Polyclonal Antibody | G-AB-09556
- 3 to 5 Working Days
- Human, Mouse, Rat
DMP1 Polyclonal Antibody | G-AB-09556 | Gentaur Antibodies
Overview: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction, Stem Cells, Developmental Biology
Synonyms: DMP1, ARHP, ARHR, DMP-1
Reactivity: Human, Mouse, Rat
Gene ID: 1758
Immunogen: Recombinant fusion protein of human DMP1 (NP_004398.1) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC, IF
Dilution: IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.