FLT3 Polyclonal Antibody | G-AB-07800

FLT3 Polyclonal Antibody | G-AB-07800 | Gentaur Antibodies

Overview: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Category Type: Polyclonal Antibody

Research Areas: Immunology, Signal Transduction

Synonyms: FLT3, CD135, FLK-2, FLK2, STK1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 2322

Accession #:

Clonality:

Immunogen: A synthetic peptide of human FLT3 (NP_004110.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P36888

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FLT3 Polyclonal Antibody DataSheet